VIP-R: Structure, Function and Therapeutic Applications (P13000)

Target Name: Vasoactive intestinal polypeptide receptor (VIP-R)

NCBI ID: P13000

Vasoactive intestinal polypeptide receptor (VIP-R)

Other Name(s): VIP-R | Vasoactive intestinal polypeptide receptor | VPAC-R

VIP-R: Structure, Function and Therapeutic Applications

Vasoactive intestinal polypeptide receptor (VIP-R) is a G protein-coupled receptor that is expressed in various tissues of the body, including the intestine, pancreas, and hypothalamus. It is a key regulator of the immune response and has been implicated in a number of biological processes, including inflammation, neurodegeneration, and obesity. Despite its importance, VIP-R is not well understood, and its role in human disease is still being explored.

In this article, we will explore the biology and potential therapeutic applications of VIP-R. We will examine its structure and function, and discuss its potential as a drug target or biomarker.

Structure and Function

VIP-R is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a critical role in cellular signaling. GPCRs are characterized by an extracellular domain that contains a transmembrane alpha-helix and a unique catalytic center. This center contains a G protein-coupled receptor tyrosine kinase (GRTK) that is responsible for the signaling of VIP-R.

VIP-R is a 21-kDa protein that is expressed in the intestine, pancreas, and hypothalamus. It is primarily localized to the basolateral layer of the intestine, where it is involved in the regulation of ion homeostasis and the immune response. VIP- R has been shown to interact with several other GPCRs, including the Transmembrane T-cell Activation Protocol (TMA) receptor, which is also involved in the regulation of ion homeostasis.

Functional assays have shown that VIP-R plays a critical role in the regulation of inflammation, neurodegeneration, and obesity. VIP-R has been shown to promote the production of pro-inflammatory cytokines, such as interleukin-1 (IL-1), and to inhibit the production of anti-inflammatory cytokines, such as IL-10. This suggests that VIP-R may be involved in the regulation of an immune response that is important for both health and disease.

VIP-R has also been shown to be involved in the regulation of energy metabolism and metabolism-related hormones. For example, VIP-R has been shown to interact with the peroxisome proliferator-activated receptor (PPAR), which is a key regulator of energy metabolism. This suggests that VIP-R may be involved in the regulation of energy homeostasis and the development of metabolic disorders.

Potential Therapeutic Applications

VIP-R is a promising drug target and may have a number of therapeutic applications. One potential target for VIP-R is the use of VIP-R agonists, which could be used to treat a variety of disorders, including obesity, type 2 diabetes , and inflammatory bowel disease.

For example, VIP-R agonists could be used to treat obesity by modulating the immune response and energy metabolism. VIP-R agonists could also be used to treat type 2 diabetes by modulating the insulin sensitivity of the body and improving the production of GLUT1, a hormone that regulates blood sugar.

Another potential application of VIP-R is the treatment of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. VIP-R has been shown to be involved in the regulation of neurodegeneration and may be a potential therapeutic target for these disorders.

VIP-R has also been shown to be involved in the regulation of cancer progression, and may be a potential therapeutic target for cancer. For example, VIP-R has been shown to be involved in the regulation of the angiogenesis factor, VEGF, which is a key regulator of cancer growth. This suggests that VIP-R may be

Protein Name: Vasoactive Intestinal Polypeptide Receptor (VIP-R) (nonspecified Subtype)

The "Vasoactive intestinal polypeptide receptor (VIP-R) Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about Vasoactive intestinal polypeptide receptor (VIP-R) comprehensively, including but not limited to:
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•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
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•   expression level;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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